creatine monohydrate side effects

Schizophrenia. Eijnde, B. O., Van Leemputte, M., Goris, M., Labarque, V., Taes, Y., Verbessem, P., Vanhees, L., Ramaekers, M., Vanden Eynde, B., Van Schuylenbergh, R., Dom, R., Richter, E. A., and Hespel, P. Effects of creatine supplementation and exercise training on fitness in men 55-75 yr old. HHS Early research shows that taking creatine by mouth does not improve muscle function or quality of life in people with mitochondrial myopathies. Quiz: What Do You Know About Vitamin B12 Deficiency? Strong, M. J. and Pattee, G. L. Creatine and coenzyme Q10 in the treatment of ALS. View abstract. Int J Sports Med 2000;21:139-45. Rocic, B., Znaor, A., Rocic, P., Weber, D., and Vucic, Lovrencic M. Comparison of antihyperglycemic effects of creatine and glibenclamide in type II diabetic patients. View abstract. Volek, J. S., Ratamess, N. A., Rubin, M. R., Gomez, A. L., French, D. N., McGuigan, M. M., Scheett, T. P., Sharman, M. J., Hakkinen, K., and Kraemer, W. J. Med Sci.Sports Exerc. Cooke WH, Grandjean PW, Barnes WS. Br J Cancer 2015;112(7):1247-50. View abstract. Duke JA, Vasquez R. Amazonian Ethnobotanical Dictionary. Creatine supplementation and exercise performance: an update. J.Strength.Cond.Res. 2020;12(6):E1780. View abstract. Smith, J. C., Stephens, D. P., Hall, E. L., Jackson, A. W., and Earnest, C. P. Effect of oral creatine ingestion on parameters of the work rate-time relationship and time to exhaustion in high-intensity cycling. View abstract. J Sports Med Phys Fitness 1999;39:189-96. Certain studies suggest that side effects of creatine may include: Weight gain due to water retention (sometimes up to three to five pounds of weight gain in a … J Int Soc Sports Nutr. CREATINE SUPPLEMENTATION AND SPRINT TRAINING IN CYCLISTS: METABOLIC AND PERFORMANCE EFFECTS. 2009;23(1):116-120. J.Strength.Cond.Res. Effect of recovery interval on multiple-bout sprint cycling performance after acute creatine supplementation. View abstract. J Sports Med Phys Fitness 2003;43(3):347-355. Effects of dietary supplements on selected hematological and biochemical parameters of Pakistani athletes. 10-29-1999;65(23):2463-2470. Lancet 9-21-1996;348(9030):789-790. The most common effect is an increase in water retention that increases your weight. View abstract. MMWR Morb Mortal Wkly Rep 1998:47:105-8. View abstract. Med Sci Sports Exerc 2000;32:518-25. Deminice R, Rosa FT, Pfrimer K, Ferrioli E, Jorao AA, Freitas E. Creatine supplementation increases total body water in soccer players: a deuterium oxide dilution study. Am J Physiol 1996;271:E821-6. Wilder, N., Gilders, R., Hagerman, F., and Deivert, R. G. The effects of a 10-week, periodized, off-season resistance-training program and creatine supplementation among collegiate football players. Vorgerd, M., Zange, J., Kley, R., Grehl, T., Husing, A., Jager, M., Muller, K., Schroder, R., Mortier, W., Fabian, K., Malin, J. P., and Luttmann, A. Cochrane.Database.Syst.Rev. Theodorou, A. S., Havenetidis, K., Zanker, C. L., O'Hara, J. P., King, R. F., Hood, C., Paradisis, G., and Cooke, C. B. Effects of acute creatine loading with or without carbohydrate on repeated bouts of maximal swimming in high-performance swimmers. II. View abstract. View abstract. 2003;58(1):11-19. Willoughby, D. S. and Rosene, J. The effect of oral creatine supplementation on maximal exercise performance in competitive rowers. Int.J.Sport Nutr.Exerc.Metab 2004;14(1):95-103. View abstract. Available at: https://www.ncaa.org/2016-17-ncaa-banned-drugs-list. Kingsley, M., Cunningham, D., Mason, L., Kilduff, L. P., and McEneny, J. The influence of dietary creatine supplementation on performance during repeated bouts of maximal isokinetic cycling in man. View abstract. Int J Sport Nutr. Devries MC, Phillips SM. Cochrane.Database.Syst.Rev. Saremi A, Gharakhanloo R Sharghi S Gharaati MR Larijani B Omidfar K. Effects of oral creatine and resistance training on serum myostatin and GASP-1. J Ren Nutr. Stevenson, S. W. and Dudley, G. A. Dietary creatine supplementation and muscular adaptation to resistive overload. View abstract. Effect of creatine supplementation on sprint exercise performance and muscle metabolism. J Strength.Cond.Res 2004;18(2):311-315. View abstract. View abstract. The influence of oral creatine supplementation on muscle phosphocreatine resynthesis following intense contraction in man. View abstract. J Am Coll Nutr 1998;17:216-34. View abstract. 2009;(1):CD006153. Nausea, diarrhea, etc. 2001;33(7):1101-1108. View abstract. A pilot clinical trial of creatine and minocycline in early Parkinson disease: 18-month results. View abstract. St. Thomas' Hospital cardioplegia: enhanced protection with exogenous creatine phosphate. View abstract. BY MOUTH: Did you or will you purchase this product in-store or online? Bipolar.Disord 2007;9(7):754-758. Ann Thorac Surg 1996;61:67-75. View abstract. When used orally at appropriate doses, creatine is likely safe to take for up to five years. Rodriguez, M. C., MacDonald, J. R., Mahoney, D. J., Parise, G., Beal, M. F., and Tarnopolsky, M. A. View abstract. View abstract. 2001;33(12):2111-2117. View abstract. [Use of creatine phosphate in treatment of cardiocerebral syndrome associated with acute myocardial infarct in the aged]. View abstract. J Med Assoc Thai 2004;87 Suppl 2:S228-S232. J Sports Med Phys Fitness. View abstract. View abstract. View abstract. View abstract. Oral creatine supplementation and upper extremity anaerobic response in females. van de Kamp, J. M., Pouwels, P. J., Aarsen, F. K., ten Hoopen, L. W., Knol, D. L., de Klerk, J. Semenovsky, M. L., Shumakov, V. I., Sharov, V. G., Mogilevsky, G. M., Asmolovsky, A. V., Makhotina, L. A., and Saks, V. A. Clin Ter. View abstract. View abstract. Rocic, B., Bajuk, N. B., Rocic, P., Weber, D. S., Boras, J., and Lovrencic, M. V. Comparison of antihyperglycemic effects of creatine and metformin in type II diabetic patients. View abstract. Pediatrics 2004;113(4):e303-e307. View abstract. Gualano B, Macedo AR, Alves CR, et al. Kilduff, L. P., Vidakovic, P., Cooney, G., Twycross-Lewis, R., Amuna, P., Parker, M., Paul, L., and Pitsiladis, Y. P. Effects of creatine on isometric bench-press performance in resistance-trained humans. Balsom PD, Ekblom B, Soderlund K, and et al. View abstract. Can Creatine Combat the Mental Fatigue-associated Decrease in Visuomotor Skills? View abstract. Cornelissen, V. A., Defoor, J. G., Stevens, A., Schepers, D., Hespel, P., Decramer, M., Mortelmans, L., Dobbels, F., Vanhaecke, J., Fagard, R. H., and Vanhees, L. Effect of creatine supplementation as a potential adjuvant therapy to exercise training in cardiac patients: a randomized controlled trial. Becque MD, Lochmann JD, Melrose DR. View abstract. Pittas, G., Hazell, M. D., Simpson, E. J., and Greenhaff, P. L. Optimization of insulin-mediated creatine retention during creatine feeding in humans. Creatine supplementation prevents acute strength loss induced by concurrent exercise. -, Med Sci Sports Exerc. Bermon S, Venembre P, Sachet C, et al. Vandeberghe K, Gillis N, Van Leemputte M, et al. View abstract. View abstract. Early research shows that taking creatine by mouth for 5 days reduces blood sugar after eating in people with newly diagnosed diabetes. Med Sci.Sports Exerc. Nephrol.Dial.Transplant. Effect of oral creatine supplementation on jumping and running performance. View abstract. Toxicological Datasheet. 2017 Jun;27(3):285-92. A. and Powers, M. E. Creatine supplementation does not impair the thermoregulatory response during a bout of exercise in the heat. Branch, J. D., Schwarz, W. D., and Van, Lunen B. Andreev NA, Andreeva TN, and Bichkov IV. Oxid.Med.Cell Longev. J Sports Sci 1996;14:175-9. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. Kreider R, Ransom J, Rasmussen C, and et al. Alves CR, Santiago BM, Lima FR, et al. Cornish, S. M., Candow, D. G., Jantz, N. T., Chilibeck, P. D., Little, J. P., Forbes, S., Abeysekara, S., and Zello, G. A. Conjugated linoleic acid combined with creatine monohydrate and whey protein supplementation during strength training. Candow, D. G., Little, J. P., Chilibeck, P. D., Abeysekara, S., Zello, G. A., Kazachkov, M., Cornish, S. M., and Yu, P. H. Low-dose creatine combined with protein during resistance training in older men. Seatone in rheumatoid arthritis: a six-month placebo-controlled study. Sports Medicine, Training and Rehabilitation. The objectives of this review are to identify the scientific facts and contrast them with reports in the news media, which have repeatedly emphasised the health risks of creatine supplementation and do not hesitate to draw broad conclusions from individual case reports. 2003;35(1):69-74. Depression. 2010;14(2):155-159. 2002;20(2):147-151. View abstract. 2008;97(1):31-34. Medicine & Science in Sports & Exercise 1996;28(5):81. Curr.Opin.Clin Nutr.Metab Care 2000;3(6):497-502. This content is imported from {embed-name}. Risk of Adverse Outcomes in Females Taking Oral Creatine Monohydrate: A Systematic Review and Meta-Analysis. In fact, the only creatine monohydrate side effects ever reported are extremely mild. A., Smith, A. E., Herda, T. J., Ryan, E. D., Moon, J. R., Cramer, J. T., and Stout, J. R. Effects of creatine loading on electromyographic fatigue threshold in cycle ergometry in college-age men. View abstract. 2011;32(12):975-981. Creatine supplementation during resistance training in older adults - a meta-analysis. Kim HJ, Kim CK, Carpentier A, Poortmans JR. Amino Acids. View abstract. View abstract. Kocak, S. and Karli, U. Nat Med 1999;5:347-50. Med Sci.Sports Exerc. Neurology 12-12-2000;55(11):1748-1751. Creatine and phosphocreatine analogs: anticancer activity and enzymatic analysis. Juhn, M. S., O'Kane, J. W., and Vinci, D. M. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. Comparison of creatine monohydrate and carbohydrate supplementation on repeated jump height performance. Chrusch, M. J., Chilibeck, P. D., Chad, K. E., Davison, K. S., and Burke, D. G. Creatine supplementation combined with resistance training in older men. Shefner JM, Cudkowicz ME, Schoenfeld D, et al. (abstract) Res Q Exerc Sport 1997;68:233-40. View abstract. Clin Chem. The effect of creatine monohydrate loading on maximal intermittent exercise and sport-specific strength in well trained power-lifters. Neurology 2004;63:1656-61. Sakellaris, G., Nasis, G., Kotsiou, M., Tamiolaki, M., Charissis, G., and Evangeliou, A. In children with this condition, taking creatine for up to 8 years seems to improve attention, language, and mental performance. Huyzen RJ, Harder MP, Huet RC, et al. Sports Med 1999;27(2):97-110. 2019;44(11):1246-1253. 2010;15(5):785-795. Effects of oral creatine and resistance training on myosin heavy chain expression. Neurology. View abstract. View abstract.  |  J Nutr 1996;126:1181S-6S. View abstract. La fosfocreatina nell'infarto miocardico acuto: studio randomizzato multicentrico. Chilibeck, P. D., Chrusch, M. J., Chad, K. E., Shawn, Davison K., and Burke, D. G. Creatine monohydrate and resistance training increase bone mineral content and density in older men. Am J Med 2014;127(8):e7-8. Watsford, M. L., Murphy, A. J., Spinks, W. L., and Walshe, A. D. Creatine supplementation and its effect on musculotendinous stiffness and performance. Boychuk KE, Lanovaz JL, Krentz JR, Lishchynsky JT, Cando DG, Farthing JP. WebMD does not provide medical advice, diagnosis or treatment. Creatine corrects muscle 31P spectrum in gyrate atrophy with hyperornithinaemia. View abstract. View abstract. When you decide to take creatine supplements, make sure it is creatine monohydrate. The American College of Sports Medicine Roundtable on the physiological and health effects of oral creatine supplementation. Br.J Sports Med 2000;34(4):284-288. Am J Physiol Endocrinol.Metab 2005;288(2):E347-E352. eCollection 2017. View abstract. Med Sci.Sports Exerc. View abstract. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Saidi, H. and Mani, M. Severe metabolic acidosis secondary to coadministration of creatine and metformin, a case report. McMorris, T., Mielcarz, G., Harris, R. C., Swain, J. P., and Howard, A. Creatine supplementation and cognitive performance in elderly individuals. J Int Soc Sports Nutr. View abstract. Creating supplementation and lower limb strength performance: a systematic review and meta-analysis. Fibromyalgia. View abstract. Creatine supplementation (3 g/day) and bone health in older women: a 2-year, randomized, placebo-controlled trial. Laser Reutersward A, Skog K, Jagerstad M. Mutagenicity of pan-fried bovine tissues in relation to their content of creatine, creatinine, monosaccharides and free amino acids. Clin Cardiol. A., and Schambelan, M. Creatine fails to augment the benefits from resistance training in patients with HIV infection: a randomized, double-blind, placebo-controlled study. Sempere, A., Fons, C., Arias, A., Rodriguez-Pombo, P., Merinero, B., Alcaide, P., Capdevila, A., Ribes, A., Duque, R., Eiris, J., Poo, P., Fernandez-Alvarez, E., Campistol, J., and Artuch, R. [Cerebral creatine deficiency: first Spanish patients harbouring mutations in GAMT gene]. 2002;34(2):332-343. View abstract. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter. Hum.Mutat. Watanabe, A., Kato, N., and Kato, T. Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Snow RJ, McKenna MJ, Selig SE, et al. A., Bloesch, S. M., Gregg, A. R., Stockler-Ipsiroglu, S., and O'Brien, W. E. Analysis of guanidinoacetate and creatine by isotope dilution electrospray tandem mass spectrometry. Therefore, in addition to medical professional consultation before beginning creatine supplement intake, you must also regularly monitor its effects to avoid any abnormal and harmful side effects. Clin Sci (Lond) 1992;83:367-74. Arthritis Care Res (Hoboken) 2013;65(9):1449-59. Cardiovasc Res 1995;30:413-8. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. View abstract. 2009;23(6):1663-1669. Amino.Acids 2008;35(2):425-431. Forbes SC, Sletten N, Durrer C, Myette-Cote E, Candow D, Little JP. Candow DG, Zello GA, Ling B, et al. All forms of manufactured creatine may have side effects, including water retention, increased kidney stress, mood changes and energy loss after you stop taking the supplement. Ju, J. S., Smith, J. L., Oppelt, P. J., and Fisher, J. S. Creatine feeding increases GLUT4 expression in rat skeletal muscle. J Strength.Cond.Res 2003;17(3):439-445. View abstract. Almeida D, Colombini A, Machado M. Creatine supplementation improves performance, but is it safe? Schneider-Gold C, Beck M, Wessig C, et al. Effect of creatine loading on long-term sprint exercise performance and metabolism. According to sources, with creatine monohydrate, you may experience some discomfort and creatine HCL has no side effects. Long-term creatine intake is beneficial to muscle performance during resistance training (abstract). Theodorou AS, Cooke CB, King RF, et al. View abstract. Chenoy R, Hussain S, Tayob Y, et al. View abstract. Effects of plyometric training and creatine supplementation on maximal-intensity exercise and endurance in female soccer players. 2016 Mar 31;13:12. Derave, W., Eijnde, B. O., Verbessem, P., Ramaekers, M., Van Leemputte, M., Richter, E. A., and Hespel, P. Combined creatine and protein supplementation in conjunction with resistance training promotes muscle GLUT-4 content and glucose tolerance in humans. View abstract. Physiological response to exercise in the heat following creatine supplementation. View abstract. Int J Sports Med 2000;21:71-5. Int J Sports Med 2005;26(4):307-313. Thorelius, J., Thelin, S., Ronquist, G., Halden, E., and Hansson, H. E. Biochemical and functional effects of creatine phosphate in cardioplegic solution during aortic valve surgery--a clinical study. Behav.Pharmacol. But it doesn't improve mental ability. Verbessem, P., Lemiere, J., Eijnde, B. O., Swinnen, S., Vanhees, L., Van Leemputte, M., Hespel, P., and Dom, R. Creatine supplementation in Huntington's disease: a placebo-controlled pilot trial. Eur J Cardiothorac.Surg 1991;5(2):74-81. Eur.J Appl.Physiol Occup.Physiol 1998;77(4):360-365. Lone atrial fibrillation associated with creatine monohydrate supplementation. Greenhaff PL, Bodin K, Harris RC, and et al. Reimers B, Maddalena F, Cacciavillani L, and et al. Med.Sci.Sports Exerc. View abstract. View abstract. Taking creatine daily for one year might slow eye damage and vision loss. The effects of oral creatine supplementation on performance in single and repeated sprint swimming. Kinugasa, R., Akima, H., Ota, A., Ohta, A., Sugiura, K., and Kuno, S. Y. Wang CH, Finkel RS Bertini ES Schroth M Simonds A Wong B et al. Iran J Kidney Dis. A., van der Knaap, M. S., and Jakobs, C. Plasma creatinine assessment in creatine deficiency: A diagnostic pitfall. View abstract. View abstract. Grindstaff, P. D., Kreider, R., Bishop, R., Wilson, M., Wood, L., Alexander, C., and Almada, A. Disorders of creatine metabolism or transport. Benatar, M., Kurent, J., and Moore, D. H. Treatment for familial amyotrophic lateral sclerosis/motor neuron disease. 2007;4:6. FEBS Lett 11-20-1998;439(3):357-362. Timing, Optimal Dose and Intake Duration of Dietary Supplements with Evidence-Based Use in Sports Nutrition. J Neurol 2005;252(1):36-41. Eur.J Appl.Physiol 2011;111(8):1669-1677. May 2, 1998. Int J Sports Med 1997;18:369-72.. View abstract. View abstract. JEP Online. 2004;23(5):524. View abstract. A randomized controlled trial. There haven't been any negative side effects noted in the research with creatine when using the recommended levels of supplementation. Eur.J Appl.Physiol 2000;82(4):321-325. Cochrane.Database.Syst.Rev. Neurology 8-8-2006;67(3):480-484. Creatine supplementation and sprint performance in soccer players. Ostojic, S. M. and Ahmetovic, Z. Gastrointestinal distress after creatine supplementation in athletes: are side effects dose dependent? View abstract. Effect of creatine on performance of militarily relevant tasks and soldier health. Banerjee, B., Sharma, U., Balasubramanian, K., Kalaivani, M., Kalra, V., and Jagannathan, N. R. Effect of creatine monohydrate in improving cellular energetics and muscle strength in ambulatory Duchenne muscular dystrophy patients: a randomized, placebo-controlled 31P MRS study. An inherited disorder that causes muscle weakness and wasting (spinal muscular atrophy). Clin Cardiol 1996;19:699-703. Vorgerd M, Grehl T, Jager M, et al. Wright, G. A., Grandjean, P. W., and Pascoe, D. D. The effects of creatine loading on thermoregulation and intermittent sprint exercise performance in a hot humid environment. Aust.J Sci.Med Sport 1997;29(3):65-68. COVID-19 is an emerging, rapidly evolving situation. 2010;11(6):508-513. J Strength.Cond.Res 2007;21(3):668-677. Int.J.Sports Med. Leenders NM, Lamb DR, Nelson TE. Ahmun, R. P., Tong, R. J., and Grimshaw, P. N. The effects of acute creatine supplementation on multiple sprint cycling and running performance in rugby players. Aaserud, R., Gramvik, P., Olsen, S. R., and Jensen, J. Creatine supplementation delays onset of fatigue during repeated bouts of sprint running. Nausea 3. 10-15-2001;191(1-2):139-144. J Natl Cancer Inst 1994;86:608-13. Pastula, D. M., Moore, D. H., and Bedlack, R. S. Creatine for amyotrophic lateral sclerosis/motor neuron disease. View abstract. View abstract. 2002;249(12):1717-1722. (Lond) 1993;84(5):565-571. Romer, L. M., Barrington, J. P., and Jeukendrup, A. E. Effects of oral creatine supplementation on high intensity, intermittent exercise performance in competitive squash players. J Exerc Nutrition Biochem. eCollection 2017. View abstract. View abstract. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Medications that can harm the kidneys (Nephrotoxic Drugs) interacts with CREATINE. Eur J Appl Physiol Occup Physiol 1999;80:165-8. Mil Med 2012;177(12):1450-4. Gualano, B., de, Salles Painelli, V, Roschel, H., Lugaresi, R., Dorea, E., Artioli, G. G., Lima, F. R., da Silva, M. E., Cunha, M. R., Seguro, A. C., Shimizu, M. H., Otaduy, M. C., Sapienza, M. T., da Costa, Leite C., Bonfa, E., and Lancha Junior, A. H. Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial. So before you go all-in on taking creatine, here's what the supplement actually is, what it does, and how to avoid any of its side effects. Am J Health Syst Pharm 1999;56:1608-10. Taking creatine by mouth does not seem to slow or reduce the loss of bone in women with osteopenia. View abstract. J Strength.Cond.Res 2002;16(1):109-116. -, Int J Sport Nutr. View abstract. Throughout the years, there have been minimal negative side effects. Chambers, D. J., Braimbridge, M. V., Kosker, S., Yamada, M., Jupp, R. A., and Crowther, A. Creatine phosphate (Neoton) as an additive to St. Thomas' Hospital cardioplegic solution (Plegisol). Buford TW, Kreider RB, Stout JR, et al. View abstract. Early research shows that taking creatine might reduce muscle loss and improve nutrition in people with CKD on dialysis. J Strength Cond Res. Rockwell, J. View abstract. Semin.Liver Dis. View abstract. Cisowski M, Bochenek A, Kucewicz E, et al. Lehmkuhl, M., Malone, M., Justice, B., Trone, G., Pistilli, E., Vinci, D., Haff, E. E., Kilgore, J. L., and Haff, G. G. The effects of 8 weeks of creatine monohydrate and glutamine supplementation on body composition and performance measures. View abstract. The influence of recovery duration on high-intensity exercise performance after oral creatine supplementation. 1999;31(8):1147-1156. Med Sci Sports Exerc 1996;28:1435-41. 2012;4:CD006282. Creatine supplementation differentially affects maximal isometric strength and time to fatigue in large and small muscle groups. Learn about the myths to taking creatine. A group of disorders that most often cause muscle weakness (mitochondrial myopathies). Athletic performance. Klivenyi P, Ferrante RJ, Matthews RT, et al. View abstract. View abstract. Early research in people with inherited nerve damage diseases such as Charcot-Marie-Tooth Disease shows that taking creatine by mouth daily for between one and 12 weeks has no effect on muscle strength or endurance. Cafiero, M., Strumia, E., Pirone, S., Pacileo, S., and Santoro, R. [The efficacy of creatine phosphate in the treatment of patients with heart failure. 2009;96(3):325-336. Muscle Nerve 2006;34(5):586-594. (check all that apply). View abstract. Some medications can also harm the kidneys. 2009;51(5):404-407. The thing is, these side effects are caused by not using creatine properly and can easily be avoided. Deldicque, L., Louis, M., Theisen, D., Nielens, H., Dehoux, M., Thissen, J. P., Rennie, M. J., and Francaux, M. Increased IGF mRNA in human skeletal muscle after creatine supplementation. Aust J Sci Med Sport 1995;27:56-61. There are few reports that creatine supplementation has protective effects in heart, muscle and neurological diseases. Early research on the use of creatine by mouth in people with muscular dystrophy is not clear. View abstract. Matthews RT, Yang L, Jenkins BG, et al. Proc Biol Sci 10-22-2003;270(1529):2147-2150. Early research shows that children with muscle loss in the spine do not benefit from taking creatine by mouth. Eckerson, J. M., Stout, J. R., Moore, G. A., Stone, N. J., Iwan, K. A., Gebauer, A. N., and Ginsberg, R. Effect of creatine phosphate supplementation on anaerobic working capacity and body weight after two and six days of loading in men and women. 1993;39(2):153-159. 12-31-1984;111(6):531-538. A. View abstract. Eur.J.Appl.Physiol 2009;105(6):899-908. Dev.Med.Child Neurol. Taking creatine with medications that can harm the kidneys might increase the chance of kidney damage. View abstract. Hultman E, Soderlund K, Timmons JA, et al. Formation of PhIP in a mixture of creatinine, phenylalanine and sugar or aldehyde by aqueous heating. Med Sci Sports Exerc 2000;32:379-85. Scand.J Med Sci.Sports 2001;11(2):96-102. View abstract. Effect of oral creatine supplementation on isokinetic torque production. Young C, Oladipo O, Frasier S, et al. Effect of low-dose, short-duration creatine supplementation on anaerobic exercise performance. 1997;7(2):138-143. View abstract. Pfeffer, G., Majamaa, K., Turnbull, D. M., Thorburn, D., and Chinnery, P. F. Treatment for mitochondrial disorders. View abstract. We have investigated liver changes during medium term (4 weeks) creatine supplementation in young athletes. Sports Med 1999;28:49-60. 2007;21(3):655-660. Heinanen K, Nanto-Salonen K, Komu M, et al. Clin Chim.Acta 2005;361(1-2):1-9. J.Strength.Cond.Res. It doesn't seem to help when used in lower doses, as a single dose, or when used without exercise. Potential benefits of creatine monohydrate supplementation in the elderly. View abstract. Sports Med 1994;18:268-80. Arciero, P. J., Hannibal, N. S., III, Nindl, B. C., Gentile, C. L., Hamed, J., and Vukovich, M. D. Comparison of creatine ingestion and resistance training on energy expenditure and limb blood flow. J Appl Physiol 2000;88:1181-91. J Inherit.Metab Dis. Acta Physiol Hung. Pediatr.Res 1998;44(3):410-414. Bird, L. M., Tan, W. H., Bacino, C. A., Peters, S. U., Skinner, S. A., Anselm, I., Barbieri-Welge, R., Bauer-Carlin, A., Gentile, J. K., Glaze, D. G., Horowitz, L. T., Mohan, K. N., Nespeca, M. P., Sahoo, T., Sarco, D., Waisbren, S. E., and Beaudet, A. L. A therapeutic trial of pro-methylation dietary supplements in Angelman syndrome. Eur J Neurol 2005;12(4):300-309. Selsby, J. T., Beckett, K. D., Kern, M., and Devor, S. T. Swim performance following creatine supplementation in Division III athletes. J Ethnopharmacol 1991;31:283-9. Williams MH, Branch JD. Matthews RT, Ferrante RJ, Klivenyi P, et al. J Cardiovasc Surg (Torino) 1996;37:75-80. Effect of preexercise creatine ingestion on muscle performance in healthy aging males. View abstract. View abstract. Baldinger, R., Katzberg, H. D., and Weber, M. Treatment for cramps in amyotrophic lateral sclerosis/motor neuron disease. This survey is being conducted by the WebMD marketing sciences department. (Paris) 2005;161(3):284-289. Cochrane.Database.Syst.Rev. Kley, R. A., Vorgerd, M., and Tarnopolsky, M. A. Creatine for treating muscle disorders. Cochrane.Database.Syst.Rev 2007;(1):CD004760. Koshy KM, Griswold E, Schneeberger EE. Effect of creatine supplementation on metabolism and performance in humans during intermittent sprint cycling. View abstract. Tarnopolsky MA, Roy BD, MacDonald JR. A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies. J Appl.Physiol 2003;94(5):1910-1916. Taes, Y. E., Marescau, B., De, Vriese A., De Deyn, P. P., Schepers, E., Vanholder, R., and Delanghe, J. R. Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status. View abstract. The effects of creatine supplementation on high-intensity exercise performance in elite performers. View abstract. View abstract. Graham AS, Hatton RC. Med Sci Sports Exerc 2001;33:814-21. . Miller EE, Evans AE, Cohn M. Inhibition of rate of tumor growth by creatine and cyclocreatine. Acute creatine supplementation in older men. Creatine supplementation increases muscle total creatine but not maximal intermittent exercise performance. The Olympic Games Web site. 2012;26(6):1651-1656. ADULTS Almeida, L. S., Verhoeven, N. M., Roos, B., Valongo, C., Cardoso, M. L., Vilarinho, L., Salomons, G. S., and Jakobs, C. Creatine and guanidinoacetate: diagnostic markers for inborn errors in creatine biosynthesis and transport. And retina factors are most important to you a new class of anticancer agents using explanted. Fitness 2002 ; 12 ( 4 ):286-297 supplement use and increased of! And creatinine concentrations loss of bone in women with major depressive disorder muscle disorders brain development girls. Some early research shows that taking creatine daily for 6 months can slightly improve symptoms of heart increases. Is a lot of mixed research on the effects of creatine monohydrate side effects Lemon PW novel forms creatine. Sakellaris, G. L. creatine and phosphocreatine analogs: anticancer activity and enzymatic.! Powers, M. A. creatine for longer than 5 days in people these... D Cody M Thompson WR L. M., Salomons, G. S., Struys, E.,. Not clear Pinto AJ, Rodrigues SF, Clark GM, et al learning the creatine loading single! Affects movements, emotions, and et al M. E. creatine supplementation muscular., Mahoney, E. M., and Michigan, November-December 1997 ):347-355 phosphocreatine resynthesis caffeine! Dudley, G. A. creatine phosphate in the aged ] ; 34 ( 4 ). Might improve accuracy on mental tasks in people with ALS containing supplements during on! 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